For zhuhai candesartan ester medicine generation mechanics we may not be very understanding, small make up to introduce the following:

Candesartan ester of candesartan precursor drugs, in the gastrointestinal tract absorption is quickly and completely during hydrolysis of candesartan, absolute bioavailability of candesartan is about 15%, the concentration of plasma candesartan tmax for 3-4 hours. The combination of candesartan and plasma protein rate is greater than 99%, the distribution of apparent volume of 0.13 L/kg. Rats experiment proved that candesartan rarely through the blood brain barrier, but through the placental barrier and distribution to the fetus.

Candesartan in prototype mainly by the urinary and fecal excretion, few in the liver by O - to generate inactive metabolites ethylation reaction. Candesartan the excretion of half-life of about nine hours. High blood pressure in patients with oral 2 - l6mg/day, 4 weeks continuous administration, candesartan plasma clearance of 14.07 L/h, terminal elimination half-life of 9 - l3 hours. The data shows, the total clearance for the candesartan is 0., renal clearance of 0.19 ml; Oral 14 c candesartan ester, recovery of 33% and 33% respectively in the urine, dung radioactivity.

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