To affect the omeprazole enteric factors on the quality of the micro pill have? The zhuhai omeprazole micro pill professionals to introduce:

(1) using extrusion - rolling method of micro pill, except in the material in the process of preparation of the function of the adhesive force, also by plus mechanical extrusion, into micro pill by low porosity, density is big, difficult to collapse and drug release slowly.

2 omeprazole API does not dissolve in water, its size in a certain extent affect the release of drugs, adopting micronization processed raw materials (diameter < 20 microns), is expected to improve the dissolution rate.

(3) starch and MCC itself can be used as disintegrating agent, but mainly in the preparations as a diluent, efficient disintegrating agent is added in the prescription, such as low crosslinking povidone, replace the hydroxypropyl cellulose (HPC) L, such as the disintegration rate will accelerate, drug release rate will be increased.

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